Physiologically Based Pharmacokinetic Modelling of Cytochrome P450 2C9-Related Tolbutamide Drug Interactions with Sulfaphenazole and Tasisulam

BACKGROUND AND OBJECTIVES: Cytochrome P450 2C9 (CYP2C9) is involved in the biotransformation of many commonly used drugs, and significant drug interactions have been reported for CYP2C9 substrates. Previously published physiologically based pharmacokinetic (PBPK) models of tolbutamide are based on a...

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Detalles Bibliográficos
Autores principales: Perkins, Everett J., Posada, Maria, Kellie Turner, P., Chappell, Jill, Ng, Wee Teck, Twelves, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2017
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956062/
https://www.ncbi.nlm.nih.gov/pubmed/29119333
http://dx.doi.org/10.1007/s13318-017-0447-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956062/
https://www.ncbi.nlm.nih.gov/pubmed/29119333
http://dx.doi.org/10.1007/s13318-017-0447-5

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