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A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications

The problem of the genetics of related phenotypes is often addressed by analyzing adjusted-model traits, but such traits warrant cautious interpretation. Here, we adopt a joint view of adiposity traits in ~322,154 subjects (GIANT consortium). We classify 159 signals associated with body mass index (...

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Detalles Bibliográficos
Autores principales: Winkler, Thomas W, Günther, Felix, Höllerer, Simon, Zimmermann, Martina, Loos, Ruth JF, Kutalik, Zoltán, Heid, Iris M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956079/
https://www.ncbi.nlm.nih.gov/pubmed/29769528
http://dx.doi.org/10.1038/s41467-018-04124-9