Functional effects of TrkA inhibition on system x(C)(−)-mediated glutamate release and cancer-induced bone pain

Breast cancer cells release the signalling molecule glutamate via the system x(C)(−) antiporter, which is upregulated to exchange extracellular cystine for intracellular glutamate to protect against oxidative stress. Here, we demonstrate that this antiporter is functionally influenced by the actions...

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Detalles Bibliográficos
Autores principales: Miladinovic, Tanya, Ungard, Robert G, Linher-Melville, Katja, Popovic, Snezana, Singh, Gurmit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956640/
https://www.ncbi.nlm.nih.gov/pubmed/29761734
http://dx.doi.org/10.1177/1744806918776467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956640/
https://www.ncbi.nlm.nih.gov/pubmed/29761734
http://dx.doi.org/10.1177/1744806918776467

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