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Functional effects of TrkA inhibition on system x(C)(−)-mediated glutamate release and cancer-induced bone pain
Breast cancer cells release the signalling molecule glutamate via the system x(C)(−) antiporter, which is upregulated to exchange extracellular cystine for intracellular glutamate to protect against oxidative stress. Here, we demonstrate that this antiporter is functionally influenced by the actions...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
SAGE Publications
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956640/ https://www.ncbi.nlm.nih.gov/pubmed/29761734 http://dx.doi.org/10.1177/1744806918776467 |