Efficacies of Cabotegravir and Bictegravir against drug-resistant HIV-1 integrase mutants

BACKGROUND: Integrase strand transfer inhibitors (INSTIs) are the class of antiretroviral (ARV) drugs most recently approved by the FDA for the treatment of HIV-1 infections. INSTIs block the strand transfer reaction catalyzed by HIV-1 integrase (IN) and have been shown to potently inhibit infection...

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Detalles Bibliográficos
Autores principales: Smith, Steven J., Zhao, Xue Zhi, Burke, Terrence R., Hughes, Stephen H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956922/
https://www.ncbi.nlm.nih.gov/pubmed/29769116
http://dx.doi.org/10.1186/s12977-018-0420-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956922/
https://www.ncbi.nlm.nih.gov/pubmed/29769116
http://dx.doi.org/10.1186/s12977-018-0420-7

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