G9a stimulates CRC growth by inducing p53 Lys373 dimethylation-dependent activation of Plk1

Rationale: G9a is genetically deregulated in various tumor types and is important for cell proliferation; however, the mechanism underlying G9a-induced carcinogenesis, especially in colorectal cancer (CRC), is unclear. Here, we investigated if G9a exerts oncogenic effects in CRC by increasing polo-l...

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Detalles Bibliográficos
Autores principales: Zhang, Jie, Wang, Yafang, Shen, Yanyan, He, Pengxing, Ding, Jian, Chen, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957015/
https://www.ncbi.nlm.nih.gov/pubmed/29774081
http://dx.doi.org/10.7150/thno.23824

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957015/
https://www.ncbi.nlm.nih.gov/pubmed/29774081
http://dx.doi.org/10.7150/thno.23824

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