Impact of targeting transforming growth factor β-2 with antisense OT-101 on the cytokine and chemokine profile in patients with advanced pancreatic cancer

BACKGROUND: Overexpression of the cytokine – transforming growth factor-beta 2 (TGF-β2) – has been implicated in the malignant progression of pancreatic cancer (PAC). OT-101 (trabedersen) is an antisense oligodeoxynucleotide designed to target the human TGF-β2 mRNA. In a Phase I/II study, OT-101 tre...

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Detalles Bibliográficos
Autores principales: D’Cruz, Osmond J, Qazi, Sanjive, Hwang, Larn, Ng, Kevin, Trieu, Vuong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957068/
https://www.ncbi.nlm.nih.gov/pubmed/29785126
http://dx.doi.org/10.2147/OTT.S161905

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957068/
https://www.ncbi.nlm.nih.gov/pubmed/29785126
http://dx.doi.org/10.2147/OTT.S161905

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