Randomized phase I trial HIV-CORE 003: Depletion of serum amyloid P component and immunogenicity of DNA vaccination against HIV-1

BACKGROUND: The failure of DNA vaccination in humans, in contrast to its efficacy in some species, is unexplained. Observational and interventional experimental evidence suggests that DNA immunogenicity may be prevented by binding of human serum amyloid P component (SAP). SAP is the single normal DN...

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Detalles Bibliográficos
Autores principales: Borthwick, Nicola J., Lane, Thirusha, Moyo, Nathifa, Crook, Alison, Shim, Jung Min, Baines, Ian, Wee, Edmund G., Hawkins, Philip N., Gillmore, Julian D., Hanke, Tomáš, Pepys, Mark B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957335/
https://www.ncbi.nlm.nih.gov/pubmed/29772028
http://dx.doi.org/10.1371/journal.pone.0197299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957335/
https://www.ncbi.nlm.nih.gov/pubmed/29772028
http://dx.doi.org/10.1371/journal.pone.0197299

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