A multi-center preclinical study of gadoxetate DCE-MRI in rats as a biomarker of drug induced inhibition of liver transporter function

Drug-induced liver injury (DILI) is a leading cause of acute liver failure and transplantation. DILI can be the result of impaired hepatobiliary transporters, with altered bile formation, flow, and subsequent cholestasis. We used gadoxetate dynamic contrast-enhanced magnetic resonance imaging (DCE-M...

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Detalles Bibliográficos
Autores principales: Karageorgis, Anastassia, Lenhard, Stephen C., Yerby, Brittany, Forsgren, Mikael F., Liachenko, Serguei, Johansson, Edvin, Pilling, Mark A., Peterson, Richard A., Yang, Xi, Williams, Dominic P., Ungersma, Sharon E., Morgan, Ryan E., Brouwer, Kim L. R., Jucker, Beat M., Hockings, Paul D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957399/
https://www.ncbi.nlm.nih.gov/pubmed/29771932
http://dx.doi.org/10.1371/journal.pone.0197213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957399/
https://www.ncbi.nlm.nih.gov/pubmed/29771932
http://dx.doi.org/10.1371/journal.pone.0197213

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