Growth medium-dependent antimicrobial activity of early stage MEP pathway inhibitors

The in vivo microenvironment of bacterial pathogens is often characterized by nutrient limitation. Consequently, conventional rich in vitro culture conditions used widely to evaluate antibacterial agents are often poorly predictive of in vivo activity, especially for agents targeting metabolic pathw...

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Detalles Bibliográficos
Autores principales: Sanders, Sara, Bartee, David, Harrison, Mackenzie J., Phillips, Paul D., Koppisch, Andrew T., Freel Meyers, Caren L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957436/
https://www.ncbi.nlm.nih.gov/pubmed/29771999
http://dx.doi.org/10.1371/journal.pone.0197638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957436/
https://www.ncbi.nlm.nih.gov/pubmed/29771999
http://dx.doi.org/10.1371/journal.pone.0197638

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