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Growth medium-dependent antimicrobial activity of early stage MEP pathway inhibitors
The in vivo microenvironment of bacterial pathogens is often characterized by nutrient limitation. Consequently, conventional rich in vitro culture conditions used widely to evaluate antibacterial agents are often poorly predictive of in vivo activity, especially for agents targeting metabolic pathw...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957436/ https://www.ncbi.nlm.nih.gov/pubmed/29771999 http://dx.doi.org/10.1371/journal.pone.0197638 |