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Binding of sulphonylureas to plasma proteins – A K(ATP) channel perspective
Sulphonylurea drugs stimulate insulin secretion from pancreatic β-cells primarily by inhibiting ATP sensitive potassium (K(ATP)) channels in the β-cell membrane. The effective sulphonylurea concentration at its site of action is significantly attenuated by binding to serum albumin, which makes it di...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957440/ https://www.ncbi.nlm.nih.gov/pubmed/29772022 http://dx.doi.org/10.1371/journal.pone.0197634 |