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Binding of sulphonylureas to plasma proteins – A K(ATP) channel perspective

Sulphonylurea drugs stimulate insulin secretion from pancreatic β-cells primarily by inhibiting ATP sensitive potassium (K(ATP)) channels in the β-cell membrane. The effective sulphonylurea concentration at its site of action is significantly attenuated by binding to serum albumin, which makes it di...

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Detalles Bibliográficos
Autores principales:	Proks, Peter, Kramer, Holger, Haythorne, Elizabeth, Ashcroft, Frances M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957440/ https://www.ncbi.nlm.nih.gov/pubmed/29772022 http://dx.doi.org/10.1371/journal.pone.0197634

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