Structural basis for overhang excision and terminal unwinding of DNA duplexes by TREX1

Three prime repair exonuclease 1 (TREX1) is an essential exonuclease in mammalian cells, and numerous in vivo and in vitro data evidenced its participation in immunity regulation and in genotoxicity remediation. In these very complicated cellular functions, the molecular mechanisms by which duplex D...

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Detalles Bibliográficos
Autores principales: Huang, Kuan-Wei, Liu, Tung-Chang, Liang, Ruei-Yue, Chu, Lee-Ya, Cheng, Hiu-Lo, Chu, Jhih-Wei, Hsiao, Yu-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957452/
https://www.ncbi.nlm.nih.gov/pubmed/29734329
http://dx.doi.org/10.1371/journal.pbio.2005653

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957452/
https://www.ncbi.nlm.nih.gov/pubmed/29734329
http://dx.doi.org/10.1371/journal.pbio.2005653

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