Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria

DNA damage accumulates with age (Lombard et al., 2005). However, whether and how robust DNA repair machinery promotes longevity is elusive. Here, we demonstrate that ATM-centered DNA damage response (DDR) progressively declines with senescence and age, while low dose of chloroquine (CQ) activates AT...

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Detalles Bibliográficos
Autores principales: Qian, Minxian, Liu, Zuojun, Peng, Linyuan, Tang, Xiaolong, Meng, Fanbiao, Ao, Ying, Zhou, Mingyan, Wang, Ming, Cao, Xinyue, Qin, Baoming, Wang, Zimei, Zhou, Zhongjun, Wang, Guangming, Gao, Zhengliang, Xu, Jun, Liu, Baohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957528/
https://www.ncbi.nlm.nih.gov/pubmed/29717979
http://dx.doi.org/10.7554/eLife.34836

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957528/
https://www.ncbi.nlm.nih.gov/pubmed/29717979
http://dx.doi.org/10.7554/eLife.34836

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