Perlecan, a heparan sulfate proteoglycan, regulates systemic metabolism with dynamic changes in adipose tissue and skeletal muscle

Perlecan (HSPG2), a heparan sulfate proteoglycan, is a component of basement membranes and participates in a variety of biological activities. Here, we show physiological roles of perlecan in both obesity and the onset of metabolic syndrome. The perinatal lethality-rescued perlecan knockout (Hspg2(−...

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Detalles Bibliográficos
Autores principales: Yamashita, Yuri, Nakada, Satoshi, Yoshihara, Toshinori, Nara, Takeshi, Furuya, Norihiko, Miida, Takashi, Hattori, Nobutaka, Arikawa-Hirasawa, Eri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958100/
https://www.ncbi.nlm.nih.gov/pubmed/29773865
http://dx.doi.org/10.1038/s41598-018-25635-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958100/
https://www.ncbi.nlm.nih.gov/pubmed/29773865
http://dx.doi.org/10.1038/s41598-018-25635-x

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