A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration

Rhodopsin homeostasis is tightly coupled to rod photoreceptor cell survival and vision. Mutations resulting in the misfolding of rhodopsin can lead to autosomal dominant retinitis pigmentosa (adRP), a progressive retinal degeneration that currently is untreatable. Using a cell-based high-throughput...

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Detalles Bibliográficos
Autores principales: Chen, Yuanyuan, Chen, Yu, Jastrzebska, Beata, Golczak, Marcin, Gulati, Sahil, Tang, Hong, Seibel, William, Li, Xiaoyu, Jin, Hui, Han, Yong, Gao, Songqi, Zhang, Jianye, Liu, Xujie, Heidari-Torkabadi, Hossein, Stewart, Phoebe L., Harte, William E., Tochtrop, Gregory P., Palczewski, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958115/
https://www.ncbi.nlm.nih.gov/pubmed/29773803
http://dx.doi.org/10.1038/s41467-018-04261-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958115/
https://www.ncbi.nlm.nih.gov/pubmed/29773803
http://dx.doi.org/10.1038/s41467-018-04261-1

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