Novel pathway of 3-hydroxyanthranilic acid formation in limazepine biosynthesis reveals evolutionary relation between phenazines and pyrrolobenzodiazepines

Natural pyrrolobenzodiazepines (PBDs) form a large and structurally diverse group of antitumour microbial metabolites produced through complex pathways, which are encoded within biosynthetic gene clusters. We sequenced the gene cluster of limazepines and proposed their biosynthetic pathway based on...

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Detalles Bibliográficos
Autores principales: Pavlikova, Magdalena, Kamenik, Zdenek, Janata, Jiri, Kadlcik, Stanislav, Kuzma, Marek, Najmanova, Lucie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958127/
https://www.ncbi.nlm.nih.gov/pubmed/29773836
http://dx.doi.org/10.1038/s41598-018-26179-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958127/
https://www.ncbi.nlm.nih.gov/pubmed/29773836
http://dx.doi.org/10.1038/s41598-018-26179-w

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