CD4(+) T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema

T cell-mediated responses have been implicated in the development of fibrosis, impaired lymphangiogenesis, and lymphatic dysfunction in secondary lymphedema. Here we show that CD4(+) T cells are necessary for lymphedema pathogenesis by utilizing adoptive transfer techniques in CD4 knockout mice that...

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Detalles Bibliográficos
Autores principales: García Nores, Gabriela D., Ly, Catherine L., Cuzzone, Daniel A., Kataru, Raghu P., Hespe, Geoffrey E., Torrisi, Jeremy S., Huang, Jung Ju, Gardenier, Jason C., Savetsky, Ira L., Nitti, Matthew D., Yu, Jessie Z., Rehal, Sonia, Mehrara, Babak J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958132/
https://www.ncbi.nlm.nih.gov/pubmed/29773802
http://dx.doi.org/10.1038/s41467-018-04418-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958132/
https://www.ncbi.nlm.nih.gov/pubmed/29773802
http://dx.doi.org/10.1038/s41467-018-04418-y

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