Unified approach for extrapolation and bridging of adult information in early-phase dose-finding paediatric studies

The number of trials conducted and the number of patients per trial are typically small in paediatric clinical studies. This is due to ethical constraints and the complexity of the medical process for treating children. While incorporating prior knowledge from adults may be extremely valuable, this...

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Detalles Bibliográficos
Autores principales: Petit, Caroline, Samson, Adeline, Morita, Satoshi, Ursino, Moreno, Guedj, Jérémie, Jullien, Vincent, Comets, Emmanuelle, Zohar, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958415/
https://www.ncbi.nlm.nih.gov/pubmed/27705884
http://dx.doi.org/10.1177/0962280216671348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958415/
https://www.ncbi.nlm.nih.gov/pubmed/27705884
http://dx.doi.org/10.1177/0962280216671348

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