Effect of membrane-bound complement regulatory proteins on tumor cell sensitivity to complement-dependent cytolysis triggered by heterologous expression of the α-gal xenoantigen

Engineering malignant cells to express a heterologous α-gal antigen can induce heterograft hyperacute rejection, resulting in complement-dependent cytolysis (CDC) of tumor cells, which has been considered as a novel strategy for antitumor therapy. A549 cells engineered to express Galα1-3Galβ1-4GlcNA...

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Detalles Bibliográficos
Autores principales: Wang, Yu, Liao, Juan, Yang, Ya-Jun, Wang, Zhu, Qin, Feng, Zhu, Sheng-Ming, Zheng, Hong, Wang, Yan-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958734/
https://www.ncbi.nlm.nih.gov/pubmed/29805637
http://dx.doi.org/10.3892/ol.2018.8478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958734/
https://www.ncbi.nlm.nih.gov/pubmed/29805637
http://dx.doi.org/10.3892/ol.2018.8478

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