A Novel Catecholopyrimidine Based Small Molecule PDE4B Inhibitor Suppresses Inflammatory Cytokines in Atopic Mice

Degradation of cyclic adenosine mono phosphate (cAMP) by phosphodiesterase-4B (PDE-4B) in the inflammatory cells leads to elevated expression of inflammatory cytokines in inflammatory cells. Suppression of cytokines has proved to be beneficial in the treatment of atopic dermatitis (AD). Henceforth,...

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Detalles Bibliográficos
Autores principales: Purushothaman, Baskaran, Arumugam, Parthasarathy, Song, Joon Myong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958743/
https://www.ncbi.nlm.nih.gov/pubmed/29867490
http://dx.doi.org/10.3389/fphar.2018.00485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958743/
https://www.ncbi.nlm.nih.gov/pubmed/29867490
http://dx.doi.org/10.3389/fphar.2018.00485

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