Cargando…
A Novel Catecholopyrimidine Based Small Molecule PDE4B Inhibitor Suppresses Inflammatory Cytokines in Atopic Mice
Degradation of cyclic adenosine mono phosphate (cAMP) by phosphodiesterase-4B (PDE-4B) in the inflammatory cells leads to elevated expression of inflammatory cytokines in inflammatory cells. Suppression of cytokines has proved to be beneficial in the treatment of atopic dermatitis (AD). Henceforth,...
Autores principales: | Purushothaman, Baskaran, Arumugam, Parthasarathy, Song, Joon Myong |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958743/ https://www.ncbi.nlm.nih.gov/pubmed/29867490 http://dx.doi.org/10.3389/fphar.2018.00485 |
Ejemplares similares
-
Use of a Fission Yeast Platform to Identify and Characterize Small Molecule PDE Inhibitors
por: Hoffman, Charles S.
Publicado: (2022) -
Inkjet Bioprinting
on Parchment Paper for Hit Identification
from Small Molecule Libraries
por: Lee, Jungmi, et al.
Publicado: (2019) -
Inhaled Phosphodiesterase 4 (PDE4) Inhibitors for Inflammatory Respiratory Diseases
por: Phillips, Jonathan E.
Publicado: (2020) -
Targeting Cytokine Signaling and Lymphocyte Traffic via Small Molecules in Inflammatory Bowel Disease: JAK Inhibitors and S1PR Agonists
por: Pérez-Jeldres, Tamara, et al.
Publicado: (2019) -
Perspectives of PDE inhibitor on treating idiopathic pulmonary fibrosis
por: Yang, Xudan, et al.
Publicado: (2023)