DARPP-32 and t-DARPP promote non-small cell lung cancer growth through regulation of IKKα-dependent cell migration

Lung cancer is the leading cause of cancer-related death worldwide. Here we demonstrate that elevated expression of dopamine and cyclic adenosine monophosphate-regulated phosphoprotein, Mr 32000 (DARPP-32), and its truncated splice variant t-DARPP promote lung tumor growth, while abrogation of DARPP...

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Detalles Bibliográficos
Autores principales: Alam, Sk. Kayum, Astone, Matteo, Liu, Ping, Hall, Stephanie R., Coyle, Abbygail M., Dankert, Erin N., Hoffman, Dane K., Zhang, Wei, Kuang, Rui, Roden, Anja C., Mansfield, Aaron S., Hoeppner, Luke H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959014/
https://www.ncbi.nlm.nih.gov/pubmed/29782621
http://dx.doi.org/10.1038/s42003-018-0050-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959014/
https://www.ncbi.nlm.nih.gov/pubmed/29782621
http://dx.doi.org/10.1038/s42003-018-0050-6

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