Acetyl-CoA-directed gene transcription in cancer cells

Fluctuations in acetyl-coenzyme A (acetyl-CoA) levels have been previously associated with changes in global histone acetylation and gene expression. The study by Lee and colleagues (pp. 497–511) in this issue of Genes & Development demonstrates that acetyl-CoA can promote the up-regulation of c...

Descripción completa

Detalles Bibliográficos
Autores principales: Martínez-Reyes, Inmaculada, Chandel, Navdeep S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Outlook
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959230/
https://www.ncbi.nlm.nih.gov/pubmed/29692354
http://dx.doi.org/10.1101/gad.315168.118
Descripción
Sumario:Fluctuations in acetyl-coenzyme A (acetyl-CoA) levels have been previously associated with changes in global histone acetylation and gene expression. The study by Lee and colleagues (pp. 497–511) in this issue of Genes & Development demonstrates that acetyl-CoA can promote the up-regulation of cell migration- and adhesion-related genes in glioblastoma by controlling Ca(2+)–NFAT (nuclear factor of activated T cells) signaling.

Ejemplares similares