Acetyl-CoA-directed gene transcription in cancer cells

Fluctuations in acetyl-coenzyme A (acetyl-CoA) levels have been previously associated with changes in global histone acetylation and gene expression. The study by Lee and colleagues (pp. 497–511) in this issue of Genes & Development demonstrates that acetyl-CoA can promote the up-regulation of c...

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Detalles Bibliográficos
Autores principales: Martínez-Reyes, Inmaculada, Chandel, Navdeep S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Outlook
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959230/
https://www.ncbi.nlm.nih.gov/pubmed/29692354
http://dx.doi.org/10.1101/gad.315168.118
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author Martínez-Reyes, Inmaculada
Chandel, Navdeep S.
author_facet Martínez-Reyes, Inmaculada
Chandel, Navdeep S.
author_sort Martínez-Reyes, Inmaculada
collection PubMed
description Fluctuations in acetyl-coenzyme A (acetyl-CoA) levels have been previously associated with changes in global histone acetylation and gene expression. The study by Lee and colleagues (pp. 497–511) in this issue of Genes & Development demonstrates that acetyl-CoA can promote the up-regulation of cell migration- and adhesion-related genes in glioblastoma by controlling Ca(2+)–NFAT (nuclear factor of activated T cells) signaling.
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spelling pubmed-59592302018-10-01 Acetyl-CoA-directed gene transcription in cancer cells Martínez-Reyes, Inmaculada Chandel, Navdeep S. Genes Dev Outlook Fluctuations in acetyl-coenzyme A (acetyl-CoA) levels have been previously associated with changes in global histone acetylation and gene expression. The study by Lee and colleagues (pp. 497–511) in this issue of Genes & Development demonstrates that acetyl-CoA can promote the up-regulation of cell migration- and adhesion-related genes in glioblastoma by controlling Ca(2+)–NFAT (nuclear factor of activated T cells) signaling. Cold Spring Harbor Laboratory Press 2018-04-01 /pmc/articles/PMC5959230/ /pubmed/29692354 http://dx.doi.org/10.1101/gad.315168.118 Text en © 2018 Martínez-Reyes and Chandel; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Outlook
Martínez-Reyes, Inmaculada
Chandel, Navdeep S.
Acetyl-CoA-directed gene transcription in cancer cells
title Acetyl-CoA-directed gene transcription in cancer cells
title_full Acetyl-CoA-directed gene transcription in cancer cells
title_fullStr Acetyl-CoA-directed gene transcription in cancer cells
title_full_unstemmed Acetyl-CoA-directed gene transcription in cancer cells
title_short Acetyl-CoA-directed gene transcription in cancer cells
title_sort acetyl-coa-directed gene transcription in cancer cells
topic Outlook
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959230/
https://www.ncbi.nlm.nih.gov/pubmed/29692354
http://dx.doi.org/10.1101/gad.315168.118
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