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Transcriptional coactivator PGC-1α contains a novel CBP80-binding motif that orchestrates efficient target gene expression

Although peroxisome proliferator-activated receptor-γ (PPARγ) coactivator 1α (PGC-1α) is a well-established transcriptional coactivator for the metabolic adaptation of mammalian cells to diverse physiological stresses, the molecular mechanism by which it functions is incompletely understood. Here we...

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Detalles Bibliográficos
Autores principales: Cho, Hana, Rambout, Xavier, Gleghorn, Michael L., Nguyen, Phuong Quoc Thuc, Phipps, Christopher R., Miyoshi, Keita, Myers, Jason R., Kataoka, Naoyuki, Fasan, Rudi, Maquat, Lynne E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959238/
https://www.ncbi.nlm.nih.gov/pubmed/29654059
http://dx.doi.org/10.1101/gad.309773.117