EIF2B2 mutations in vanishing white matter disease hypersuppress translation and delay recovery during the integrated stress response

Mutations in eIF2B genes cause vanishing white matter disease (VWMD), a fatal leukodystrophy that can manifest following physical trauma or illness, conditions that activate the integrated stress response (ISR). EIF2B is the guanine exchange factor for eIF2, facilitating ternary complex formation an...

Descripción completa

Detalles Bibliográficos
Autores principales: Moon, Stephanie L., Parker, Roy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959252/
https://www.ncbi.nlm.nih.gov/pubmed/29632131
http://dx.doi.org/10.1261/rna.066563.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959252/
https://www.ncbi.nlm.nih.gov/pubmed/29632131
http://dx.doi.org/10.1261/rna.066563.118

Ejemplares similares