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EIF2B2 mutations in vanishing white matter disease hypersuppress translation and delay recovery during the integrated stress response
Mutations in eIF2B genes cause vanishing white matter disease (VWMD), a fatal leukodystrophy that can manifest following physical trauma or illness, conditions that activate the integrated stress response (ISR). EIF2B is the guanine exchange factor for eIF2, facilitating ternary complex formation an...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959252/ https://www.ncbi.nlm.nih.gov/pubmed/29632131 http://dx.doi.org/10.1261/rna.066563.118 |