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Defining essential elements and genetic interactions of the yeast Lsm2–8 ring and demonstration that essentiality of Lsm2–8 is bypassed via overexpression of U6 snRNA or the U6 snRNP subunit Prp24
A seven-subunit Lsm2–8 protein ring assembles on the U-rich 3′ end of the U6 snRNA. A structure-guided mutational analysis of the Saccharomyces cerevisiae Lsm2–8 ring affords new insights to structure–function relations and genetic interactions of the Lsm subunits. Alanine scanning of 39 amino acids...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959253/ https://www.ncbi.nlm.nih.gov/pubmed/29615482 http://dx.doi.org/10.1261/rna.066175.118 |