Quantification of Apixaban, Dabigatran, Edoxaban, and Rivaroxaban in Human Serum by UHPLC-MS/MS—Method Development, Validation, and Application

BACKGROUND: Direct oral anticoagulants (DOACs) are prescribed for anticoagulation in patients with atrial fibrillation and venous thromboembolic disease. Fixed doses are recommended, but measuring their serum drug concentrations as a basis for dose adjustments may be useful in some clinical settings...

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Detalles Bibliográficos
Autores principales: Lindahl, Sofia, Dyrkorn, Roar, Spigset, Olav, Hegstad, Solfrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Therapeutic Drug Monitoring 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959258/
https://www.ncbi.nlm.nih.gov/pubmed/29578938
http://dx.doi.org/10.1097/FTD.0000000000000509

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959258/
https://www.ncbi.nlm.nih.gov/pubmed/29578938
http://dx.doi.org/10.1097/FTD.0000000000000509

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