Effects of Cytochrome P450 (CYP) 2C19 Genotypes on Steady-State Plasma Concentrations of Escitalopram and its Desmethyl Metabolite in Japanese Patients With Depression

BACKGROUND: Plasma concentrations of the S-enantiomer of citalopram were different between extensive and poor CYP2C19 metabolizers in healthy subjects and depressed patients. However, most studies applied dose-corrected concentrations. Thus, we studied the effects of polymorphisms of the CYP2C19 gen...

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Detalles Bibliográficos
Autores principales: Tsuchimine, Shoko, Ochi, Shinichiro, Tajiri, Misuzu, Suzuki, Yutaro, Sugawara, Norio, Inoue, Yoshimasa, Yasui-Furukori, Norio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Therapeutic Drug Monitoring 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959260/
https://www.ncbi.nlm.nih.gov/pubmed/29570504
http://dx.doi.org/10.1097/FTD.0000000000000506

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959260/
https://www.ncbi.nlm.nih.gov/pubmed/29570504
http://dx.doi.org/10.1097/FTD.0000000000000506

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