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Conformational ensembles of RNA oligonucleotides from integrating NMR and molecular simulations

RNA molecules are key players in numerous cellular processes and are characterized by a complex relationship between structure, dynamics, and function. Despite their apparent simplicity, RNA oligonucleotides are very flexible molecules, and understanding their internal dynamics is particularly chall...

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Detalles Bibliográficos
Autores principales: Bottaro, Sandro, Bussi, Giovanni, Kennedy, Scott D., Turner, Douglas H., Lindorff-Larsen, Kresten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959319/
https://www.ncbi.nlm.nih.gov/pubmed/29795785
http://dx.doi.org/10.1126/sciadv.aar8521