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Stepwise control of host–guest interaction using a coordination polymer gel
Precise control of host–guest interaction as seen in biological processes is difficult to achieve with artificial systems. Herein we have exploited the thermodynamic benefits of a system in equilibrium to achieve controlled stepwise release and capture of cyclodextrin (guest) using a coordination po...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959896/ https://www.ncbi.nlm.nih.gov/pubmed/29777098 http://dx.doi.org/10.1038/s41467-018-04303-8 |
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author | Mukhopadhyay, Rahul Dev Das, Gourab Ajayaghosh, Ayyappanpillai |
author_facet | Mukhopadhyay, Rahul Dev Das, Gourab Ajayaghosh, Ayyappanpillai |
author_sort | Mukhopadhyay, Rahul Dev |
collection | PubMed |
description | Precise control of host–guest interaction as seen in biological processes is difficult to achieve with artificial systems. Herein we have exploited the thermodynamic benefits of a system in equilibrium to achieve controlled stepwise release and capture of cyclodextrin (guest) using a coordination polymer (Mg-CP) as the host and temperature as the stimulus. Since temperature is not a precision stimulus for artificial host–guest interaction, the present system is a distinct prototype that manifests temperature-controlled natural host–guest interaction. The described coordination polymeric host system, when incorporated into a hydrogel matrix, provides a microenvironment that facilitates the stepwise release of α-CD in response to temperature variation within a quasi-solid state. The work demonstrated here may pave the way towards thermally controlled delivery and monitoring of otherwise spectroscopically silent molecules such as cyclodextrins. |
format | Online Article Text |
id | pubmed-5959896 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-59598962018-05-21 Stepwise control of host–guest interaction using a coordination polymer gel Mukhopadhyay, Rahul Dev Das, Gourab Ajayaghosh, Ayyappanpillai Nat Commun Article Precise control of host–guest interaction as seen in biological processes is difficult to achieve with artificial systems. Herein we have exploited the thermodynamic benefits of a system in equilibrium to achieve controlled stepwise release and capture of cyclodextrin (guest) using a coordination polymer (Mg-CP) as the host and temperature as the stimulus. Since temperature is not a precision stimulus for artificial host–guest interaction, the present system is a distinct prototype that manifests temperature-controlled natural host–guest interaction. The described coordination polymeric host system, when incorporated into a hydrogel matrix, provides a microenvironment that facilitates the stepwise release of α-CD in response to temperature variation within a quasi-solid state. The work demonstrated here may pave the way towards thermally controlled delivery and monitoring of otherwise spectroscopically silent molecules such as cyclodextrins. Nature Publishing Group UK 2018-05-18 /pmc/articles/PMC5959896/ /pubmed/29777098 http://dx.doi.org/10.1038/s41467-018-04303-8 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Mukhopadhyay, Rahul Dev Das, Gourab Ajayaghosh, Ayyappanpillai Stepwise control of host–guest interaction using a coordination polymer gel |
title | Stepwise control of host–guest interaction using a coordination polymer gel |
title_full | Stepwise control of host–guest interaction using a coordination polymer gel |
title_fullStr | Stepwise control of host–guest interaction using a coordination polymer gel |
title_full_unstemmed | Stepwise control of host–guest interaction using a coordination polymer gel |
title_short | Stepwise control of host–guest interaction using a coordination polymer gel |
title_sort | stepwise control of host–guest interaction using a coordination polymer gel |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959896/ https://www.ncbi.nlm.nih.gov/pubmed/29777098 http://dx.doi.org/10.1038/s41467-018-04303-8 |
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