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Calcimimetic acts on enteric neuronal CaSR to reverse cholera toxin-induced intestinal electrolyte secretion

Treatment of acute secretory diarrheal illnesses remains a global challenge. Enterotoxins produce secretion through direct epithelial action and indirectly by activating enteric nervous system (ENS). Using a microperfused colonic crypt technique, we have previously shown that R568, a calcimimetic th...

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Detalles Bibliográficos
Autores principales: Tang, Lieqi, Jiang, Lingli, McIntyre, Megan E., Petrova, Ekaterina, Cheng, Sam X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959902/
https://www.ncbi.nlm.nih.gov/pubmed/29777154
http://dx.doi.org/10.1038/s41598-018-26171-4