Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor

G protein-coupled receptors (GPCRs) activate heterotrimeric G proteins by mediating a GDP to GTP exchange in the Gα subunit. This leads to dissociation of the heterotrimer into Gα-GTP and Gβγ dimer. The Gα-GTP and Gβγ dimer each regulate a variety of downstream pathways to control various aspects of...

Descripción completa

Detalles Bibliográficos
Autores principales: Gulati, Sahil, Jin, Hui, Masuho, Ikuo, Orban, Tivadar, Cai, Yuan, Pardon, Els, Martemyanov, Kirill A., Kiser, Philip D., Stewart, Phoebe L., Ford, Christopher P., Steyaert, Jan, Palczewski, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959942/
https://www.ncbi.nlm.nih.gov/pubmed/29777099
http://dx.doi.org/10.1038/s41467-018-04432-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959942/
https://www.ncbi.nlm.nih.gov/pubmed/29777099
http://dx.doi.org/10.1038/s41467-018-04432-0

Ejemplares similares