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Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor

G protein-coupled receptors (GPCRs) activate heterotrimeric G proteins by mediating a GDP to GTP exchange in the Gα subunit. This leads to dissociation of the heterotrimer into Gα-GTP and Gβγ dimer. The Gα-GTP and Gβγ dimer each regulate a variety of downstream pathways to control various aspects of...

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Detalles Bibliográficos
Autores principales:	Gulati, Sahil, Jin, Hui, Masuho, Ikuo, Orban, Tivadar, Cai, Yuan, Pardon, Els, Martemyanov, Kirill A., Kiser, Philip D., Stewart, Phoebe L., Ford, Christopher P., Steyaert, Jan, Palczewski, Krzysztof
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959942/ https://www.ncbi.nlm.nih.gov/pubmed/29777099 http://dx.doi.org/10.1038/s41467-018-04432-0

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