A computational study of hedgehog signalling involved in basal cell carcinoma reveals the potential and limitation of combination therapy

BACKGROUND: The smoothened (SMO) receptor is an essential component of the Sonic hedgehog (SHH) signalling, which is associated with the development of skin basal cell carcinoma (BCC). SMO inhibitors are indicated for BCC patients when surgical treatment or radiation therapy are not possible. Unfort...

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Detalles Bibliográficos
Autores principales: Buetti-Dinh, Antoine, Jensen, Rebecca, Friedman, Ran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960207/
https://www.ncbi.nlm.nih.gov/pubmed/29776351
http://dx.doi.org/10.1186/s12885-018-4451-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960207/
https://www.ncbi.nlm.nih.gov/pubmed/29776351
http://dx.doi.org/10.1186/s12885-018-4451-1

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