The partial dissociation of MHC class I–bound peptides exposes their N terminus to trimming by endoplasmic reticulum aminopeptidase 1

Endoplasmic reticulum aminopeptidase 1 (ERAP1) and ERAP2 process N-terminally extended antigenic precursors for optimal loading onto major histocompatibility complex class I (MHC I) molecules. We and others have demonstrated that ERAP1 processes peptides bound to MHC I, but the underlying mechanism...

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Detalles Bibliográficos
Autores principales: Papakyriakou, Athanasios, Reeves, Emma, Beton, Mary, Mikolajek, Halina, Douglas, Leon, Cooper, Grace, Elliott, Tim, Werner, Jörn M., James, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961055/
https://www.ncbi.nlm.nih.gov/pubmed/29599287
http://dx.doi.org/10.1074/jbc.RA117.000313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961055/
https://www.ncbi.nlm.nih.gov/pubmed/29599287
http://dx.doi.org/10.1074/jbc.RA117.000313

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