Human RTEL1 stabilizes long G-overhangs allowing telomerase-dependent over-extension

Telomere maintenance protects the cell against genome instability and senescence. Accelerated telomere attrition is a characteristic of premature aging syndromes including Dyskeratosis congenita (DC). Mutations in hRTEL1 are associated with a severe form of DC called Hoyeraal-Hreidarsson syndrome (H...

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Detalles Bibliográficos
Autores principales: Porreca, Rosa M, Glousker, Galina, Awad, Aya, Matilla Fernandez, Maria I, Gibaud, Anne, Naucke, Christian, Cohen, Scott B, Bryan, Tracy M, Tzfati, Yehuda, Draskovic, Irena, Londoño-Vallejo, Arturo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961080/
https://www.ncbi.nlm.nih.gov/pubmed/29522136
http://dx.doi.org/10.1093/nar/gky173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961080/
https://www.ncbi.nlm.nih.gov/pubmed/29522136
http://dx.doi.org/10.1093/nar/gky173

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