Designer epigenome modifiers enable robust and sustained gene silencing in clinically relevant human cells

Targeted modulation of gene expression represents a valuable approach to understand the mechanisms governing gene regulation. In a therapeutic context, it can be exploited to selectively modify the aberrant expression of a disease-causing gene or to provide the target cells with a new function. Here...

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Detalles Bibliográficos
Autores principales: Mlambo, Tafadzwa, Nitsch, Sandra, Hildenbeutel, Markus, Romito, Marianna, Müller, Maximilian, Bossen, Claudia, Diederichs, Sven, Cornu, Tatjana I, Cathomen, Toni, Mussolino, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961145/
https://www.ncbi.nlm.nih.gov/pubmed/29538770
http://dx.doi.org/10.1093/nar/gky171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961145/
https://www.ncbi.nlm.nih.gov/pubmed/29538770
http://dx.doi.org/10.1093/nar/gky171

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