MIR137 schizophrenia-associated locus controls synaptic function by regulating synaptogenesis, synapse maturation and synaptic transmission

The MIR137 locus is a replicated genetic risk factor for schizophrenia. The risk-associated allele is reported to increase miR-137 expression and miR-137 overexpression alters synaptic transmission in mouse hippocampus. We investigated the cellular mechanisms underlying these observed effects in mou...

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Detalles Bibliográficos
Autores principales: He, Enqi, Lozano, Miguel A Gonzalez, Stringer, Sven, Watanabe, Kyoko, Sakamoto, Kensuke, den Oudsten, Frank, Koopmans, Frank, Giamberardino, Stephanie N, Hammerschlag, Anke, Cornelisse, L Niels, Li, Ka Wan, van Weering, Jan, Posthuma, Danielle, Smit, August B, Sullivan, Patrick F, Verhage, Matthijs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961183/
https://www.ncbi.nlm.nih.gov/pubmed/29635364
http://dx.doi.org/10.1093/hmg/ddy089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961183/
https://www.ncbi.nlm.nih.gov/pubmed/29635364
http://dx.doi.org/10.1093/hmg/ddy089

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