A natural non-Watson–Crick base pair in human mitochondrial tRNA(Thr) causes structural and functional susceptibility to local mutations

Six pathogenic mutations have been reported in human mitochondrial tRNA(Thr) (hmtRNA(Thr)); however, the pathogenic molecular mechanism remains unclear. Previously, we established an activity assay system for human mitochondrial threonyl-tRNA synthetase (hmThrRS). In the present study, we surveyed t...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Yong, Zeng, Qi-Yu, Zheng, Wen-Qiang, Ji, Quan-Quan, Zhou, Xiao-Long, Wang, En-Duo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961198/
https://www.ncbi.nlm.nih.gov/pubmed/29648639
http://dx.doi.org/10.1093/nar/gky243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961198/
https://www.ncbi.nlm.nih.gov/pubmed/29648639
http://dx.doi.org/10.1093/nar/gky243

Ejemplares similares