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A natural non-Watson–Crick base pair in human mitochondrial tRNA(Thr) causes structural and functional susceptibility to local mutations
Six pathogenic mutations have been reported in human mitochondrial tRNA(Thr) (hmtRNA(Thr)); however, the pathogenic molecular mechanism remains unclear. Previously, we established an activity assay system for human mitochondrial threonyl-tRNA synthetase (hmThrRS). In the present study, we surveyed t...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961198/ https://www.ncbi.nlm.nih.gov/pubmed/29648639 http://dx.doi.org/10.1093/nar/gky243 |