5-Azacytidine treatment induces demethylation of DAPK1 and MGMT genes and inhibits growth in canine mammary gland tumor cells

BACKGROUND: Canine mammary gland tumors (CMGTs) are the most common, spontaneous types of neoplasias in female dogs. Aberrant DAPK1 and MGMT methylation associated with tumor formation and development in various cancers. 5-Azacytidine is a known specific demethylation drug that covalently binds to D...

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Detalles Bibliográficos
Autores principales: Ren, Xiaoli, Li, Huatao, Song, Xianyi, Wu, Yuhong, Liu, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961471/
https://www.ncbi.nlm.nih.gov/pubmed/29844679
http://dx.doi.org/10.2147/OTT.S162381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961471/
https://www.ncbi.nlm.nih.gov/pubmed/29844679
http://dx.doi.org/10.2147/OTT.S162381

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