lncRNA MIR100HG-derived miR-100 and miR-125b mediate cetuximab resistance via Wnt/β-catenin signaling

De novo and acquired resistance, largely attributed to genetic alterations, are barriers to effective anti-EGFR therapy. We generated cetuximab-resistant cells following prolonged cetuximab exposure to cetuximab-sensitive colorectal cancer cells in three-dimensional culture. Through whole exome sequ...

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Detalles Bibliográficos
Autores principales: Lu, Yuanyuan, Zhao, Xiaodi, Liu, Qi, Li, Cunxi, Graves-Deal, Ramona, Cao, Zheng, Singh, Bhuminder, Franklin, Jeffrey L., Wang, Jing, Hu, Huaying, Wei, Tianying, Yang, Mingli, Yeatman, Timothy J., Lee, Ethan, Saito-Diaz, Kenyi, Hinger, Scott, Patton, James G., Chung, Christine H., Emmrich, Stephan, Klusmann, Jan-Henning, Fan, Daiming, Coffey, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961502/
https://www.ncbi.nlm.nih.gov/pubmed/29035371
http://dx.doi.org/10.1038/nm.4424

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961502/
https://www.ncbi.nlm.nih.gov/pubmed/29035371
http://dx.doi.org/10.1038/nm.4424

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