A Network-Biology Informed Computational Drug Repositioning Strategy to Target Disease Risk Trajectories and Comorbidities of Peripheral Artery Disease

Currently, drug discovery approaches focus on the design of therapies that alleviate an index symptom by reengineering the underlying biological mechanism in agonistic or antagonistic fashion. For example, medicines are routinely developed to target an essential gene that drives the disease mechanis...

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Detalles Bibliográficos
Autores principales: Shameer, Khader, Dow, Garrett, Glicksberg, Benjamin S., Johnson, Kipp W., Ze, Yi, Tomlinson, Max S., Readhead, Ben, Dudley, Joel T., Kullo, Iftikhar J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Informatics Association 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961807/
https://www.ncbi.nlm.nih.gov/pubmed/29888052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961807/
https://www.ncbi.nlm.nih.gov/pubmed/29888052

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