Molecular basis of inhibition of acid sensing ion channel 1A by diminazene

Acid-sensing ion channels (ASICs) are trimeric proton-gated cation permeable ion channels expressed primarily in neurons. Here we employed site-directed mutagenesis and electrophysiology to investigate the mechanism of inhibition of ASIC1a by diminazene. This compound inhibits mouse ASIC1a with a ha...

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Detalles Bibliográficos
Autores principales: Krauson, Aram J., Rooney, James G., Carattino, Marcelo D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962070/
https://www.ncbi.nlm.nih.gov/pubmed/29782492
http://dx.doi.org/10.1371/journal.pone.0196894

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962070/
https://www.ncbi.nlm.nih.gov/pubmed/29782492
http://dx.doi.org/10.1371/journal.pone.0196894

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