Optimized delivery of siRNA into 3D tumor spheroid cultures in situ

3D tissue culture provides a physiologically relevant and genetically tractable system for studying normal and malignant human tissues. Despite this, gene-silencing studies using siRNA has proved difficult. In this study, we have identified a cause for why traditional siRNA transfection techniques a...

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Detalles Bibliográficos
Autores principales: Morgan, R. G., Chambers, A. C., Legge, D. N., Coles, S. J., Greenhough, A., Williams, A. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962539/
https://www.ncbi.nlm.nih.gov/pubmed/29785035
http://dx.doi.org/10.1038/s41598-018-26253-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962539/
https://www.ncbi.nlm.nih.gov/pubmed/29785035
http://dx.doi.org/10.1038/s41598-018-26253-3

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