Imaging glutathione depletion in the rat brain using ascorbate-derived hyperpolarized MR and PET probes

Oxidative stress is a critical feature of several common neurologic disorders. The brain is well adapted to neutralize oxidative injury by maintaining a high steady-state concentration of small-molecule intracellular antioxidants including glutathione in astrocytes and ascorbic acid in neurons. Asco...

Descripción completa

Detalles Bibliográficos
Autores principales: Qin, Hecong, Carroll, Valerie N., Sriram, Renuka, Villanueva-Meyer, Javier E., von Morze, Cornelius, Wang, Zhen Jane, Mutch, Christopher A., Keshari, Kayvan R., Flavell, Robert R., Kurhanewicz, John, Wilson, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962598/
https://www.ncbi.nlm.nih.gov/pubmed/29786697
http://dx.doi.org/10.1038/s41598-018-26296-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962598/
https://www.ncbi.nlm.nih.gov/pubmed/29786697
http://dx.doi.org/10.1038/s41598-018-26296-6

Ejemplares similares